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肠道菌群对膳食麸质所致乳糜泻的影响

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乳糜泻是由遗传易感人群因摄入膳食麸质而诱发的一种自身免疫性肠病.麸质是一类日常膳食中广泛存在的蛋白复合物,其不易被消化道完全吸收,从而激活遗传易感个体肠道内异常的固有免疫和适应性免疫反应.最新研究支持肠道菌群紊乱是乳糜泻发生与发展的关键因素之一.本文分别综述乳糜泻发病诱因、病理和治疗策略3个方面,旨在揭示肠道菌群在乳糜泻病理中的作用,并为临床上乳糜泻的防治提供理论参考.
Impact of Gut Microbiota on Celiac Disease Induced by Dietary Gluten
Celiac disease is an autoimmune enteropathy induced by dietary gluten in genetically susceptible individuals.Gluten is a type of protein complex widely present in the daily diet,whose proteins are not easily absorbed by the di-gestive tract,thus activating abnormal innate and adaptive immune responses in the gut of genetically susceptible individ-uals.Recent research supports that intestinal flora dysbiosis is one of the key factors in the development and progression of celiac disease.This article reviewed the pathogenesis,pathology and treatment strategies of celiac disease,aiming to reveal the role of intestinal flora in celiac disease and provide theoretical reference for clinical prevention and treatment of celiac disease.

dietary glutenceliac diseasegut microbiotagut barrier

时浚元、田海芝、任正楠、潘礼龙、孙嘉

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江南大学食品学院 江苏无锡 214122

江南大学无锡医学院 江苏无锡 214122

膳食麸质 乳糜泻 肠道菌群 肠道屏障

2024

中国食品学报
中国食品科学技术学会

中国食品学报

CSTPCD北大核心EI
影响因子:1.079
ISSN:1009-7848
年,卷(期):2024.24(11)