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化妆品中激素类组分靶向及非靶向分析研究进展

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激素类药物在临床上可用于治疗系统性红斑狼疮等自身免疫性疾病,还可抑制皮肤炎症,但激素长期暴露于人体皮肤会引起一系列不良反应,对人体健康造成伤害.《化妆品安全技术规范(2015年版)》已经发布了化妆品中63种激素成分的检测方法,但实际执法中发现有商家对已有激素结构基础进行修饰,合成新的激素类化合物以逃避监管.基于此,本文综述了化妆品中非法添加激素类化合物的靶向和非靶向检测手段,旨在为化妆品质量安全监测和非法添加物的监管提供技术支持和参考依据.
Research Progress on Targeted and Non-targeted Analysis of Hormonal Components in Cosmetics
Hormones,employed clinically for treating,systemic lupus erythematosus and other autoimmune diseases,demonstrate anti-inflammatory effects when applied to the skin.However,long-term exposure of hormones to human skin can lead to adverse reactions posing health risks.The Safety and Technical Standards for Cosmetics(2015 edition)has released a method for detecting 63 hormonal components in cosmetics.Nevertheless,there is evidence of businesses modifying existing hormone structures to synthesize new compounds,evading regulatory oversight.This paper reviews targeted and non-targeted detection methods for illegally added hormonal components in cosmetics,aiming to provide technical support and references for the monitoring of cosmetic quality,safety and the regulation of illegal additives.

hormonestargeted analysisnon-targeted analysiscosmeticsqualitysafetyregulation

吴宝金、王海燕、路勇

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中国食品药品检定研究院 国家药品监督管理局化妆品研究与评价重点实验室

激素 靶向 非靶向 化妆品 质量 安全 监管

国家科技重大专项

2022FY101202

2024

中国食品药品监管
中国医药报社

中国食品药品监管

影响因子:0.099
ISSN:1673-5390
年,卷(期):2024.(1)
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