To elucidate the medicinal history of Psoraleae Fructus,this study adopts a chronological approach by analyzing ancient pharmacological texts and related medical literature while incorporating insights from contemporary Chinese medicine publications and recent scientific findings.The investigation of Psoraleae Fructus encompasses aspects such as nomenclature,botanical origin,habitat,optimal harvest timing,medicinal characteristics,and processing methods.Psoraleae Fructus was first introduced to China during the Tang Dynasty.Comparative analysis of illustrations and descriptions in pharmacological works spanning various historical periods reveal that its botanical origin has remained consistent over time:the leguminous plant Psoralea corylifolia L.and its dried mature fruits.Historically,Psoraleae Fructus was primarily imported via maritime trade,though it also grew along China's southeastern coastline.At present,imports from Myanmar constitute the primary market supply.Historical and modern records concur on the optimal harvest timing and physical characteristics of Psoraleae Fructus:it is gathered in the ninth lunar month when fully ripe.Early descriptions varied,citing red and green hues for the fruit,but by the Northern Song Dynasty,black had become the preferred color-a preference maintained throughout the Ming and Qing periods.Modern studies validate this preference,showing that mature black seeds contain higher concentrations of active constituents and yield superior results.Processing methods for Psoraleae Fructus have evolved,historically including steaming,stir-frying,roasting,and reproducing.Currently,salt roasting is the main method.This method is believed to enhance therapeutic efficacy by directing the medicine to the kidneys,warming and tonifying them,aiding Yang absorption,and preventing diarrhea.This botanical examination of Psoraleae Fructus sheds light on its historical usage,provides theoretical support for ensuring its clinical safety and efficacy,and lays the groundwork for standardizing market circulation and usage.