Synthesis and properties of responsive hyaluronic acid micelles
Hyaluronic acid(HA)is a natural polysaccharide with cancer cell targeting properties,and it can be used to construct polymeric nanocarriers sensitive to lesion environments based on special functional groups.Herein,the revers-ible addition-fragmentation chain transfer(RAFT)polymerization was used to synthesize a block copolymer of 3-acryl-amide phenylboronic acid and vinyl pyrrolidone controllably.This block copolymer was self-assembled with hyaluronic acid through the borate ester bond to form nano-micelles.Adjusting the feeding concentration of two types of polymers and optimizing the chain length ratio of copolymers can obtain the regulation of micellar hydrodynamic diameter.When the concentration of copolymer was 7.5 mg/mL,the degree of polymerization was 40 and the molecular weight ratio of block was 2.The obtained particle size could be tunable from 73.3 to 163.9 nm,which is advantageous to long circula-tion in vivo and lesion penetration.The findings indicated that the nanoparticles had suitable pH,sugar,and salt respon-siveness.In summary,a multi-responsive cancer cell targeting polymer nano-micelle has been synthesized in this study,and it exhibits great potential for applications as an antitumor drug and probe carrier.
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