Syntenin蛋白是在原核生物及真核生物中广泛存在的一类胞内衔接蛋白(adaptor proteins).Syntenin由N端结构域(N-terminal domain,NTD)、两个串联的PDZ结构域(postsynaptic density protein,disc large and zonula occludens,PDZ)和C端结构域(C-terminal domain,CTD)组成,在生物进化过程中相对保守.Syntenin蛋白的PDZ结构域可与不同膜受体C端的PDZ结合基序(PDZ-binding motif,PBM)特异性结合,PDZ结构域结合受体的多样性导致了syntenin功能的多样性.本文综述了syntenin蛋白的发现与分布及其结构特征,对syntenin在肿瘤转移、细胞质膜蛋白组装、参与动物免疫等领域的研究成果进行了较为详细的综述,同时介绍了syntenin在参与动物胚胎发育调控、血管生成和轴突生长等方面的研究进展.
Syntenin as a Multifunctional Cellular Adaptor Protein
Syntenin is one of the intracellular adaptor proteins that is genetically conserved among various animal species.It consists of two tandem PDZ (postsynaptic density protein,disc large and zonula occludens) domains,a N-terminal domain and a C-terminal domain.These PDZ domains bind to a wide range of target proteins that interacted with the C-terminal PDZ binding motifs to confer diverse and sophisticated functions,thus to influence tumor metastasis,immune regulation,intracellular signal transduction,and synaptic transmission to axonal growth,etc.The structure,distribution and the binding properties of syntenin,as well as the affected physiological functions are summarized in this review.
synteninpostsynaptic density proteindisc large and zonula occludens (PDZ) domainadaptor proteinstumor metastasis
NETL
NSTL
万方数据
维普
