淋巴细胞胞质蛋白2(lymphocyte cytosolic protein 2，LCP2)是一种衔接蛋白质，在T细胞受体信号通路中扮演重要角色，激活下游信号因子以完成机体的免疫应答过程。LCP2也在恶性肿瘤的发生发展与转移中发挥重要作用，其高表达会导致不良的预后效果，降低患者生存率，其具体作用机制涉及多条信号通路。本文不仅对LCP2 的分子结构以及基本功能进行了介绍，而且重点综合评述了LCP2通过参与NF-κB、MAPK、JAK/STAT 以及PD-1/PD-L1 信号通路调控恶性肿瘤发生与发展的分子机制。总结了LCP2作为肿瘤治疗靶点的潜在作用，为将来用于相关疾病的诊断、治疗和标志物筛选等提供理论基础和参考依据。
The Immune Regulatory Mechanism of Lymphocyte Cytoplasmic Protein 2(LCP2)in the Occurrence and Development of Malignant Tumors
Lymphocyte cytoplasmic protein 2(LCP2)is an adaptor protein that participates in the T cell receptor signal transduction pathway through activating downstream signaling factors to complete the im-mune response.LCP2 also plays an important role in the occurrence,development and metastasis of ma-lignant tumors.The high expression of LCP2 leads to adverse prognostic effects and reduces patient sur-vival rates.The specific mechanisms of these reactions involve multiple signaling pathways.Here we in-troduce the structure and basic functions of LCP2,and review the important roles that LCP2 plays in the occurrence and development of malignant tumors through participating in NF-κB,MAPK,JAK/STAT,and PD-1/PD-L1 signaling pathways.The potential role of LCP2 as a tumor treatment target was also dis-cussed for providing a theoretical basis and reference for the diagnosis,treatment,and biomarker screen-ing of relevant diseases.
lymphocyte cytoplasmic protein 2(LCP2)adaptor proteinsignaling pathwaymalignant tumor
NETL
NSTL
万方数据
维普
