Ferroptosis is a novel programmed cell death pathway,which was first proposed by Dixon in 2012.It is characterized by intracellular iron overload and oxidative damage.Aging is an inevitable process characterized by the gradual deterioration of various physiological functions,which results from multiple factors.During the aging process,physiological functions of tissues and organs become dysregu-lated and deteriorated,leading to increase drisk of disease and death,such as neurodegenerative disea-ses,cancer and cardiovascular diseases.Recently,some studies have shown that there is an inextricable link between ferroptosis and aging.Aging processes of certain cell lines and age-related diseases exhibit some properties of ferroptosis.However,it remains unclear whether there is a causal relationship between ferroptosis and aging.In this review,we summarize the features of ferroptosis and aging,and point out the common characteristics in ferroptosis and aging,such as DNA damage,redox homeostasis imbalance,mi-tochondrial dysfunction and so on.In addition,this review discusses the relationship between ferroptosis and some age-related diseases,including Parkinson's disease,Alzheimer's disease,and some types of cancers.This review summarizes the potential link between ferroptosis and aging,provides a novel per-spective on the fundamental research on ferroptosis and aging,aiming for valuable insights in the treat-ment of related diseases.
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