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SOCS3在病理性疼痛中的作用

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细胞因子信号传导抑制因子3(SOCS3)是细胞因子信号传导抑制因子蛋白质家族(SOCS)的一员。SOCS3 是一种重要的细胞内蛋白质，在体内负调控细胞因子介导的信号通路，参与机体免疫、生长、造血、新陈代谢及肿瘤增殖等各种关键过程。近年的研究发现，SOCS3 参与疼痛的调控，在神经病理性疼痛、炎性疼痛等多种类型疼痛及吗啡耐受中发生表达的变化。在坐骨神经慢性压迫损伤(CCI)模型中，磷酸二聚化的STAT3 转移到细胞核内诱导脊髓背角SOCS3 表达增加，在完全弗氏佐剂(CFA)炎性疼痛大鼠中，下丘脑室旁核(PVN)内SOCS3 在急性期蛋白质表达水平增加、其慢性期表达下降，在骨癌疼痛大鼠腰2～5 背根神经节(DRG)中SOCS3 蛋白质水平显著下降。鞘内注射SOCS3 慢病毒载体、阿司匹林触发的脂蛋白A4(ATL)和芍药苷，或通过抑制非编码RNA 表达降低非编码RNA 对SOCS3 的抑制作用，能够增加SOCS3 表达发挥镇痛作用。SOCS3 通过抑制Janus 激酶/信号转导子和转录激活子3(JAK/STAT3)信号通路及下游基因的表达，阻碍白细胞介素-1(IL-1)、IL-6 和肿瘤坏死因子α(TNF-α)等多种炎性因子的分泌，以及核因子κB(NF-κB)的激活和转移等，发挥抗炎和镇痛作用。本文主要对SOCS3 缓解疼痛的可能机制进行综述，探讨SOCS3 在病理性疼痛中的作用。
The Role of SOCS3 in the Pathologic Pain
Suppressor of cytokine signaling 3(SOCS3)is a member of the suppressor of cytokine signa-ling protein family(SOCS).SOCS3 is an important protein in cells that negatively regulates the signaling pathway mediated by cytokine in vivo and involves in a variety of key processes in the body including im-mune,growth,hematopoietic,metabolic processes and the proliferation of tumors.In recent years,it has been found that SOCS3 was involved in the regulation of pain.Changes in SOCS3 expression have been found in neuropathic pain,inflammatory pain and other types of pain as well as morphine tolerance.In the chronic constriction injury(CCI)model,the translocation of the phosphorylated and dimerized STAT3 into the nucleus induced increasing SOCS3 expression in spinal dorsal horn.In rats with complete Freund's adjuvant(CFA)-induced inflammatory pain,the expression of SOCS3 in the hypothalamic pa-raventricular nucleus(PVN)was increased in the acute phase and decreased in the chronic phase.The level of SOCS3 in the dorsal root ganglia(DRG)of the ipsilateral dorsal 2-5 was significantly decreased in the bone cancer pain model rats.Intravaginal injection of SOCS3 lentiviral vectors,or Aspirin-trig-gered Lipoxin A4(ATL),or paeoniflorin,or inhibition of non-coding RNA which decreases the inhibi-tion of non-coding RNA on SOCS3,all increases SOCS3 expression to play an analgesic role.SOCS3 has anti-inflammatory and analgesic effects through inhibiting Janus kinase/signal transducer and activator of transcription 3(JAK/STAT3)signaling pathway and the expression of downstream genes,through inhibi-ting the secretion of interleukin-1(IL-1),IL-6,tumour necrosis factor-α(TNF-α)and other inflammato-ry factors,through inhibiting the activation and transfer of nuclear factor kappa-B(NF-κB)and so on.This article mainly reviews the possible mechanisms of SOCS3 in relieving pain and discussing the role of SOCS3 in pathologic pain.

suppressor of cytokine signaling 3(SOCS3)Janus kinase(JAK)signal transducer and activator of transcription 3(STAT3)neuropathic paininflammatory pain

易小苏、王冬梅

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福建师范大学生命科学学院,福建省发育与神经生物学重点实验室,福州 350117

细胞因子信号传导抑制因子3 Janus激酶 信号转导子和转录激活子3 神经病理性痛 炎性痛

国家自然科学基金福建省自然科学基金

8140092281400922

2024

10.13865/j.cnki.cjbmb.2023.11.1235

中国生物化学与分子生物学报
中国生物化学与分子生物学会 北京大学

中国生物化学与分子生物学报

CSTPCD北大核心
影响因子：0.617
ISSN：1007-7626
年,卷(期)：2024.40(1)
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