Physiological Functions of the Aryl Hydrocarbon Receptor and Its Role in Tumorigenesis and Development
The Aryl hydrocarbon receptor(AHR),a ligand-dependent transcription factor,mediates the toxic effects of 2,3,7,8-tetrachloro-dibenzop-dioxin(TCDD)and other halogenated hydrocarbons.It be-longs to the basic Helix-Loop-Helix-PER-ARNT-SIM(bHLH-PAS)family.It is evolutionarily conserved and expressed in a variety of animals and humans.The protein undergoes conformational changes by binding to specific ligands and translocates to the nucleus to form a dimer with AHR nuclear translocator(ARNT)to regulate the expression of downstream target genes.Recent studies have found that AHR has also become a key transcription factor controlling various physiological processes such as cell proliferation and differentiation,apoptosis,migration and adhesion,revealing the important role of AHR in cell home-ostasis,host immunity and tumor development.Based on a series of studies on AHR,this paper discus-ses the functional structure of AHR,the signaling pathways,and the diversity of ligands.It focuses on its role in defense and barrier protection,regulation of autoimmune processes,participation in the regulation of the development and differentiation of B cells and various T cell subsets and the expression of cyto-kines,as well as the promotion or inhibition of tumors in different microenvironments,aiming to provide new ideas for AHR targeted therapy of related immune diseases and tumors.
NETL
NSTL
万方数据
维普
