Molecular Mechanisms of Cranial Suture Development and Craniosynostosis
The development of the skull depends on the normal bone supply of the cranial suture.During this period,the cranial suture mesenchymal stem cells undergo systematic proliferation and osteogenic dif-ferentiation to ensure the normal growth of the bone.Cranial suture cells,extracellular matrix,perioste-um and meninges form the cranial suture niche and regulate each other to ensure the normal development of the cranial suture.Clinical studies have found that the vast majority of patients with craniosynostosis are accompanied by abnormalities of dura mater and extracellular matrix(ECM).Many studies have also found that abnormal external mechanical stimuli acting on cranial sutures may also lead to abnormal crani-al suture development.Considering that the development of cranial sutures is affected by many factors,this review will introduce the research progress of microenvironment in abnormal cranial suture and me-chanical force in the regulation of cranial suture development in recent years,and summarize the molecu-lar mechanism and current research direction of craniosynostosis,so as to provide new ideas for the diag-nosis and treatment of the disease.
craniosynostosisdura materextracellular matrix(ECM)mechanical force
万方数据
维普
