NAT10 is an Acetyltransferase to Lysine and Cytidine Residues and Regulates Various Biological Processes and Diseases
The nucleolar protein N-acetyltransferase 10(NAT10)is responsible for catalyzing the acetylation of both lysine and cytidine residues.At present,plenty of studies have revealed that these acetylation modifications play vital roles in numerous physiological processes,such as telomerase activity,stress response,DNA damage re-pair,cell cycle regulation,rRNA biosynthesis regulation,mRNA stability,and translation.Additionally,NAT10 has a strong association with the progression and prognosis of human cancers and Hutchinson-Gilford premature ag-ing syndrome(HGPS).However,there are still some limitations.For example,the complete structure of NAT10 and the impact of these structures on functions are still unknown,the cellular functions mediated by NAT10 remain unclear and the exact mechanism by which NAT10 influences human cancers and HGPS progression is needed to be clarified.This review covers the structure,enzymatic activity,biological functions,as well as roles in diseases of NAT10.We also propose the limitations of current research and envision the future research directions,aiming to provide a reference for NAT 10 research.
N-acetyltransferase 10(NAT10)acetylationrRNA biosynthesismRNA stability and translation regulationHutchinson-Gilford premature aging syndrome(HGPS)
万方数据
维普
