The Role and Function of Hematopoietic Prostaglandin D Synthase in Allergic Diseases
Hematopoietic prostaglandin D synthase(HPGDS)is a glutathione-transferase enzyme that is widely distributed in a range of tissues and is found in megakaryocyte lineages as well as a number of im-mune cells.HPGDS has been identified to be involved in the regulation of allergic reactions in the body,accelerating the conversion of prostaglandin H2(PGH2)to prostaglandin D2(PGD2),and the binding of PGD2 to DP2 receptors increasing the release of inflammatory cytokines and the development of allergic reactions.In recent years,it has been discovered that HPGDS has a substantial role in allergic rhinitis,allergic asthma,eosinophilic esophagitis(EoE),and atopic dermatitis(AD).With Th2 cells in atopic dermatitis,mast cells in allergic asthma,eosinophilic granulocytes in allergic rhinitis and eosinophilic esophagitis,and other key players in various diseases,HPGDS plays a critical role in the pathogenesis of allergic reactions and inflammatory diseases and is essential for disease development.Notably,medica-tions that target HPGDS such as HQL-79,TAS-204,TAS-205,and TFC-007 can effectively treat the symptoms of many allergy disorders in which HPGDS is excessive.HPGDS can be a significant target for the treatment of associated diseases.In order to highlight the significance of HPGDS in the pathogenesis of allergic diseases and to offer fresh ideas for the creation of medications for the treatment of allergic dis-eases,this paper describes the biological functions of HPGDS,reviews the important role and research progress of HPGDS in allergic diseases,as well as the experiments of HPGDS-related target drugs.
hematopoietic prostaglandin D synthase(HPGDS)prostaglandin D2(PGD2)allergic diseasesHPGDS inhibitors
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