Research and Application Progress of Skin Tissue Engineering Based on Stem Cell and 3D Bio-printing Technology
The skin,being a highly intricate organ within the human body,has long posed a challenging and significant aspect in both clinical and research domains when constructing a bionic skin model.3D bioprinting technology has effectively addressed this issue by facilitating the creation of skin constructs.This innovative technique allows for the rapid and dependable production of bionic skin substitutes,as it enables the customization of skin shapes and the precise distribution of cells and other materials to meet the specific demands of clinical and industrial applications.Furthermore,this technology exhibits excep-tional performance,adaptability,superior resolution,reproducibility,and high throughput,rendering it suitable for diverse applications such as drug screening,cosmetic testing,and skin grafts.Consequently,it holds the potential to serve as a viable skin substitute for a larger population of individuals afflicted with burns or diabetes.The integration of 3D bioprinting technology with stem cells has provided researchers and medical professionals with increased opportunities to address skin diseases.Pluripotent stem cells are particularly promising due to their ethical acceptability and ability to be genetically customized to meet in-dividual patient's needs.This customization enables the development of cell carriers with predetermined structures,which can incorporate biomimetic hierarchies,including blood vessel networks,hair follicles,and sweat glands.These advancements aim to enhance tissue functionality and improve the aesthetic out-comes of implantation procedures.This article summarizes the current research progress in skin construc-tion using 3D bioprinting technology.It specifically highlights the distinctive features of skin construction achieved through various 3D bioprinting techniques.Additionally,it analyzes the specific requirements for skin construction that includes appendages,aiming to offer valuable insights for the development of in vitro physiological or pathological models,regenerative medicine,and clinical research within this do-main.
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