Circular RNAs:The Emerging Roles in Cancer Stem Cells
Circular RNAs(circRNAs),which are close-looped and high stabile RNA molecules,have gradually attracted scientific interest for their biological function in the physiological and pathological process,especially in cancer.Cancer stem cells(CSCs),which are a subpopulation of tumor cells that possess the characteristics of self-renewal,aberrant differentiation potential,tumorigenesis and therapeu-tic resistance.The theory of CSCs opens a new dimension for tumor cell biology and clinical oncology re-search,which needs in-depth studies by researchers and clinicians.In this review,we cover biological features of CSCs,the biological structure,function and its detection technology of circRNAs,the regula-tory mechanism of circRNAs in CSC phenotypes such as self-renewal,differentiation,proliferation and invasion.Furthermore,we explore the potential clinical value of circRNAs as CSC biomarkers for clinical diagnosis,treatment and prognosis.
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