Functions of LncRNAs and LncRNA-encoded Peptides in Breast Cancer
Long non-coding RNAs(lncRNAs)are longer than 200 nucleotides(nts)in length and partially encode peptides.Bioassay and multi-omics techniques have been used to bulk identify lncRNAs and lncRNA-encoded peptides in breast cancer.In this paper,919 lncRNA-encoded tumor-specific peptides of breast cancer in the Spencer database were analyzed by online software,and the results showed that these peptides were involved in anticancer,anti-inflammatory,and cell-penetrating activities.Breast cancer development and progression are closely related to the aberrant expression of lncRNAs,which affect breast cancer development and progression through various pathways such as encoding peptides,regulating epigenetics,and modulating immunity.Some of the lncRNA-encoded peptides are independent of lncRNAs and regulate breast cancer development and progression through epigenetic regulation,inhibition of angiogenesis,etc.lncRNAs and lncRNA-encoded peptides also have a great potential for application in the diagnosis and treatment of breast cancer.Therefore,here we systematically review the roles of lncRNAs and lncRNA-encoded peptides in the development,progression,diagnosis and treatment of breast cancer,and analyze the current challenges in this research field.
breast cancerlong non-coding RNAs(lncRNA)long non-coding RNAs(lncRNA)encoded peptide
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