Chemical Biology Techniques for Targeted Manipulation of O-GlcNAcylation
O-linked-N-acetylglucosaminylation(O-GlcNAcylation)is a type of glycosylation that widely present in eukaryotic cytoplasmic proteins or mitochondria.It affects protein properties,cell functions,disease states and so on,hence it is import to identify the roles that O-GlcNAcylations play on target proteins in living cells.The new technologies for manipulating O-GlcNAcylations on target proteins will greatly accelerate the understanding of O-GlcNAc's functions.This article briefly introduces some recent research progress of chemical biology techniques for targeted protein O-GlcNAcylation,and also analyzes the advantages and limitations of these strategies,and their future development prospects.These technologies build a powerful chemical biology toolbox,which may contribute to the diagnoses and treatments related to O-GlcNAcylation.
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