Glycosylation Modification of Host Immune Molecules and Important Infectious Diseases
Protein glycosylation,one of the most common post translational modifications(PTMs)of proteins,is widely present in living organisms.In eukaryotic cells,glycosylation modifications have a significant impact on protein folding,conformation,distribution,stability and activity.The glycosylation of glycoproteins is crucial for maintaining the order of interactions between all differentiated cells in multicellular organisms.The dysfunction of protein glycosylation may lead to the occurrence of diseases and development of infectious diseases.So far,changes in protein N/O-glycan have been identified as biomarkers for the development of tumors and certain infectious diseases.Therefore,this article reviews the glycosylation of major immune molecules such as B-cell receptor(BCR),T-cell receptor(TCR),cytokines(CK),complement and immunoglobulin(Ig),as well as the relationship between these glycosylation and infectious diseases.The aim is to understand the association between glycosylation of immune molecules and infectious diseases,and to provide new ideas and strategies for the treatment of infectious diseases.
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万方数据
维普
