PRMT1在消化系统肿瘤中的作用
The Role of PRMT1 in Digestive System Tumors
郭大金 1谭圆圆 1金艳花1
作者信息
- 1. 延边大学医学院细胞生物学与医学遗传学教研室,吉林延吉 133002
- 折叠
摘要
蛋白质精氨酸甲基转移酶1(PRMT1)是蛋白质精氨酸甲基转移酶家族中的一员,通过将甲基从S-腺苷-L-甲硫氨酸转移到末端胍基氮原子以甲基化精氨酸残基,催化精氨酸残基的单甲基化和不对称二甲基化.研究发现,PRMT1位于细胞核和细胞质内,参与哺乳动物转录调节、信号转导和DNA损伤修复等过程,并通过多种方式影响肿瘤的增殖、凋亡、转移及耐药等生物学过程,在恶性肿瘤的发生过程中发挥着十分重要的作用.此外,PRMT1还是多种癌症预后不良的生物标志物,其抑制剂能够抑制部分肿瘤的生长.PRMT1与肿瘤的生物学特性密切相关,影响癌症患者的预后.本文主要就PRMT1在消化系统肿瘤中不同的作用靶点以及参与的信号通路做一综述,并简要概括PRMT1抑制剂联合治疗策略,以期为消化系统肿瘤的临床治疗及预后提供新思路.
Abstract
As an essential member of the protein arginine methyltransferase(PRMT)family,PRMT1 has been implicated in catalyzing the monomethylation and asymmetric dimethylarginine of the arginine residue by transferring methyl groups from S-adenosine-L-methionine to a terminal guanidinyl nitrogen atom.Studies have found that PRMT1 is located in the nucleus and cytoplasm,and participates in transcription,signal transduction,and DNA damage repair in mammals.Additionally,PRMT1 has a substantial impact on proliferation,apoptosis,metastasis,and drug resistance in tumors through a variety of ways,which plays a very important role in tumorigenesis.Moreover,PRMT1 could be used as a biomarker to predict poor prognosis in many tumors,and its inhibitors can suppress the growth of some tumors.PRMT1 closely regulates the biological characteristics of tumors,affecting the prognosis of cancer patients.Herein we review the different targets and signaling pathways of PRMT1 in malignant tumors of the digestive system,and summarize the combination therapy using PRMT1 inhibitors,aiming to provide new ideas for clinical diagnosis and prognosis of digestive system tumors.
关键词
蛋白质精氨酸甲基转移酶1/甲基化/肿瘤/联合治疗Key words
protein arginine methyltransferase 1(PRMT1)/methylation/tumor/combination therapy引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据