Identification of Essential Proteins and Core Protein Groups in the Yeast PPI Network Based on Complex Network Theory
Identifying essential proteins plays a significant role in fields such as disease treatment and drug design.In this paper,we initially employed five node importance ranking algorithms to identify essential proteins in four yeast protein-protein interaction(PPI)networks.By analyzing the common essential proteins among different networks,we constructed a subnetwork of essential proteins.Subsequently,using the Jaccard index,we filtered out pairs of essential proteins within the subnetwork that exhibited similar topological characteristics.This analysis revealed the presence of six core protein groups,namely Gavin-EPG 1,Gavin-EPG 2,Babu-EPG 1,Babu-EPG 2,LCMS-EPG,and MALDI-EPG,across the four networks.Although they are predominantly ribosomal proteins,the composition of proteins within the core protein groups varies significantly among the different yeast PPI networks.The essential proteins and core protein groups identified in this paper provide important theoretical references for further research on how protein interactions on the ribosome affect peptide chain synthesis and folding.
NETL
NSTL
万方数据
维普
