With the acceleration of population aging,all kinds of cardiovascular diseases caused by car-diac aging have become a health problem that cannot be ignored.In the heart,about 95％of ATP come from the cardiomyocytes to maintain the pumping function.Mitochondrial dysfunction can lead to myocar-dial energy deficiency,cardiomyocytes damage and death,or myocardial senescence.Therefore,the in-tact function of mitochondria plays an important role in maintaining the normal function of the heart and is considered as a key feature of cardiac aging.This paper reviews cardiac aging and mitochondrial dysfunc-tion,and mainly summarizes the characteristics of aging heart and the changes in mitochondrial structure and function of senescent cardiomyocytes.We focus on the five major factors leading to cardiac aging caused by mitochondrial dysfunction,including changes in the mitochondrial numbers and morphology,mitochondrial DNA mutations,mitochondrial quality control failures,mitochondrial enzyme changes,and mitochondria-related metabolites and stress signals changes.We also summarize the treatment methods and mechanism of cardiac aging by targeting mitochondria,and discuss the current status and future di-rection of mitochondrial therapy for cardiac aging.
万方数据
维普
