The Therapeutic Potential and Application Risks of iPSC-derived Mesenchymal Stem Cells
Induced pluripotent stem cell-derived mesenchymal stem cells(iMSC)have been proposed as an alternative source to primary mesenchymal stem cells(MSC),showing multiple advantages in disease treatment research.However,it remains unclear which disease type iMSCs are more suitable and whether they carry potential risks.This study utilized high-throughput sequencing data from public databases to compare iMSC with bone marrow-derived MSC(BM-MSC),adipose-derived MSC(AD-MSC),and um-bilical cord-derived MSC(UC-MSC).Through various bioinformatics methods,including differential gene expression analysis,functional enrichment analysis,protein-protein interaction network analysis,and CMap database screening.The results indicated that iMSC possesses unique gene transcription char-acteristics,showing significant differences in gene expression compared to the three commonly used MSC types,particularly in genes related to neural and muscle development and immune regulation.Functional enrichment analysis of the differential genes further confirmed iMSC's potential advantages in treating neuro-related diseases,along with its lower immunogenicity but higher tumorigenic risk.Analysis using the CMap database identified potential gene targets and small molecule inhibitors to mitigate the tumori-genic risk of iMSC,providing possible strategies to reduce the risks associated with iMSC application.In summary,as a potential source for cell therapy,iMSC shows promising advantages in treating neurological diseases,but its safety needs to be validated through further experiments and clinical studies.
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