Fascin displays elevated expression in malignant tumors,such as esophageal squamous cell carcinoma,and exerts a pro-cancer effect that is closely associated with poor prognosis among cancer pa-tients.In recent years,our research,along with that of others,has consistently demonstrated that phos-phorylation or acetylation modifications can effectively reverse the oncogenic function of Fascin,just like the"face-changing"in Sichuan Opera.Recently,we have further revealed that post-translational modifi-cations of Fascin affect the anticancer efficacy of small-molecule Fascin inhibitors.This finding suggests that therapeutics targeting Fascin should incorporate the status of post-translational modifications of Fascin into the drug efficacy evaluation framework.Here,we present a review on the oncogenic function of Fas-cin,focusing on discussing the effect of post-translational modifications on the function of Fascin and the efficacy of small-molecule Fascin inhibitors,and provide insights into future research directions in the field of Fascin.
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