The adipose tissue serves as the largest energy storage and endocrine organ in the body.It plays a crucial role in regulating energy homeostasis and hormone secretion.However,with aging,the adipose tissue undergoes significant changes that can have detrimental effects on overall health.One of the key features of aging adipose tissue is the presence of senescent cells.These cells touch neighboring cells through the secretion of cytokines and the release of metabolites.This interaction can disrupt the normal function of adipose tissues and lead to systemic chronic inflammation or metabolic disorders.Cur-rently,the microenvironment of the aging adipose tissue has not been fully clarified.Therefore,here we review the changes in the microenvironment of aging adipose tissues,including various cell types in the adipose tissue,fibrosis caused by extracellular matrix accumulation,cytokine and metabolites.These al-terations can lead to systemic chronic low-grade inflammation,insulin resistance,and premature aging.Finally,several strategies expected to delay adipose tissue aging are introduced,including improving adi-pocyte thermogenesis,senolytics,diet and exercise.This review aims to provide ta heoretical reference for the treatment of ageing-related diseases.
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