Applications of the Single Base Editing Technology in the Treatment of Hereditary Anemia
Single base editors(BEs)are a new class of base editors derived from the CRISPR/Cas sys-tem or transcription activator-like effector(TALE)gene editing technology,which can accurately edit a single base without introducing DNA double-strand-breaks or donor DNA.Compared with the previous genome editing technologies,it has the advantages of less by-products,higher editing efficiency,and lar-ger base editing range,which can be used for the treatment of genetic anemia caused by point mutations.In this paper,the development of single base editing technology and its progress in gene therapy for trea-ting genetic anemia caused by gene mutations are summarized,which can provide a theoretical reference for the clinical trial of gene therapy for clinical anemia.
single base editor(BEs)hereditary anemiagene mutation
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