Senolytic and CAR-cellular Therapies in Antiaging Medicine
The human lifespan has gradually increased,and the proportion of the elderly population in the world continues to increase,but the healthy lifespan has not kept pace.Aging is still a major risk factor for diseases such as tumors,cardiovascular diseases and Alzheimer's disease.Preventing and treating age-related diseases,and prolonging the healthy lifespan of the elderly are hot issues in scientific research.Cellular senescence is one of the 12 major signs of aging and is prevalent in the overall aging process of the body.The aging process of the organism inevitably involves cellular senescence.The elimination of senescent cells by the transgenic technology,genetic reprogramming technology,and the use of new anti-aging drugs such as senomorphic and senolytic have become an important strategy to delay aging,treat aging-related diseases,and prolong healthy lifespan.Immunosenescence is a part of body aging,and immune cells are the first cell population in the human body to undergo aging.Anti-aging therapies targeting the immune system,such as the antibody therapy,CAR-cellular therapy,and NK cell therapy,have become a hot topic in aging research in recent years,and researchers believe that immunotherapy has high clinical anti-aging potential.This review describes the characteristics of cellular senescence and immunosenescence,and then summarizes the current non-targeted intervention methods for senescence and the intervention methods for targeted elimination of senescent cells,their advantages and disadvantages,and focuses on the immunotherapy strategies for targeted elimination of senescent cells.We aim to clarify the development and limitations of various senescent cell elimination methods,and provide new clinical strategies for the prevention and treatment of aging-related diseases and extension of healthy lifespan.
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