Meta-Analysis of Green Tea and Risk of Oral Cancer
[Objective]To clarify the relationship between green tea and the risk of oral cancer through meta-analysis.[Method]We searched databases including CNKI、Wanfang、VIP、CBM、The Cochrane Library、PubMed、Web of Science and Embase from inception to April 30,2023.Rev Man 5.4 software was used for meta-analysis.[Result]A total of 12 papers were included,with a total sample size(cases/controls)of 4 259/45 141.Meta-analysis revealed that green tea intake was a protective factor for oral cancer development[OR=0.86,95％CL=(0.78,0.94),P=0.002].intake≥500 mL[OR=0.67,95％CL=(0.56,0.80),P＜0.0001],years≥20 years[0R=0.56,95％CL=(0.42,0.77),P=0.000 3],green tea moderate concentration[OR=0.58,95％CL=(0.48,0.69),P＜0.000 01],and warm tea[OR=0.40,95％CI=(0.29,0.53),P＜0.000 01]were protective factors for oral carcinogenesis;milk and green tea consumption were synergistically protective[OR=0.44,95％CL=(0.35,0.56),P＜0.000 01].[Conclusion]Green tea intake is a protective factor against oral cancer;milk consumption can have a synergistic effect with green tea;it is recommended to insist to long-term tea consumption,with a daily green tea intake of ≥500mL,and pay attention to the appropriate concentration and temperature.
green teaoral cancerCase-Control Studyrisk factorMeta-Analysis
万方数据
维普
