Association of Dietary Inflammation Index with Mucosal Lesion Severity and Inflammation Level in Adult Patients with Chronic Atrophic Gastritis
[Objective]To investigate the association between dietary inflammation index(DII)and the severity of mucosal lesions and the level of inflammation in adult patients with chronic atrophic gastritis.[Method]Totally 58 patients diagnosed with chronic atrophic gastritis in the gastroenterology department of Wuhu First People's Hospital from January 2021 to December 2022 were selected as the observation group,while 60 patients diagnosed with non-atrophic gastritis in our hospital were included as the control group,and further divided into mild group,moderate group and severe group according to different degrees of lesions of gastric antrum and stomach body.DII,interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor(TNF-α)were compared in each group.[Result]DII and inflammation levels in observation group were higher than those in control group(P＜0.05).In different degrees of gastric antrum atrophy,there were 19 cases in the mild group,26 cases in the moderate group and 13 cases in the severe group.In different degrees of gastric body atrophy,there were 18 cases in the mild group,14 cases in the moderate group and 10 cases in the severe group.DII and inflammation levels were the highest in the severe group,followed by the moderate group and the lowest in the mild group.DII was positively correlated with the levels of IL-6,CRP,TNF-α in patients(P＜0.05).In Model B,compared with low-proinflammatory diet,the risk of mucosal le-sions in adult chronic atrophic gastritis patients with high-proinflammatory diet increased by 1.57 times(OR 2.57,95％CI:1.14-5.73).Linear trend test showed that the higher DII,the greater the risk of mucosal lesions in adult chronic atrophic gastritis patients(P=0.035).[Conclusion]Pro-inflammatory diet has a certain correlation with the degree of mucosal lesions and the level of inflammation in adults with chronic atrophic gastritis.Reasonable reduction of pro-inflammatory food intake may be beneficial to reduce the risk of mucosal lesions in adults with chronic atrophic gastritis.
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