Effects of Vitamin D Supplementation on Glucose and Lipid Metabolism,Inflammatory Factors in Type 2 Diabetes Mellitus:A Meta-analysis
[Objective]To systematically evaluate the effects of vitamin D supplementation on glucose and lipid metabolism,inflam-matory factors in type 2 diabetes mellitus.[Method]The electronic databases including PubMed,Web of Science,Embase,The Cochrane Library,CNKI,WanFang Data were searched to collect randomized controlled trials about vitamin D supplementation for type 2 diabetes mellitus from inception to February 2022.Two reviewers independently screened literature that met the inclusion and exclusion criteria,extracted data and assessed the risk of bias of included studies.Then Meta-analysis was conducted by RevMan 5.3 and Stata 12.0 softwares.[Result]A total of 25 RCTs involving 1 916 patients were included(963 cases in the experimental group and 953 cases in the control group).The results of Meta-analysis showed that compared with the control group,the vitamin D supplementation group had a significant improvement in fasting blood-glucose(FBG)[SMD=-7.73,95%CI(-12.10,-3.36),P=0.000 5],triglyceride(TG)[SMD=-24.03,95%CI(-29.47,-18.58),P＜0.000 01],high density lipoprotein cholesterol(HDL-C)[SMD=2.76,95%CI(0.84,4.69),P=0.005],low density lipoprotein cholesterol(LDL-C)[SMD=-2.93,95%CI(-4.32,-1.54),P＜0.000 1]and hypersensitive creac-tive protein(hs-CRP)[SMD=-1.00,95%CI(-1.61,-0.38),P=0.002],but there were no significant differences in levels of glycosyl-ated hemoglobin(HbA1c)[(SMD=-0.19,95%CI(-0.47,-0.10),P=0.2],total cholesterol(TC)[SMD=-6.6,95%CI(-12.17,-1.03),P=0.02]and tumor necrosis factor-α(TNF-α)[SMD=-2.09,95%CI(-4.31,0.13),P=0.06].[Conclusion]Vitamin D supplementation can improve FBG,HOMA-IR,TG,HDL-C,LDL-C and hs-CRP,but can not improve the levels of HbA1c,TC and TNF-α.Due to limited quality and quantity of the included studies,more high quality studies are required to verify above conclusions.
type 2 diabetes mellitusvitamin Drandomized controlled trialsMeta-analysis
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