Effect of Vitamin D Combined with Dietary Management on Glycaemic Control and Pregnancy Outcome in Patients with Gestational Diabetes Mellitus
[Objective]To investigate the effect of vitamin D combined with dietary management on glycaemic control and maternal and fetal pregnancy outcomes in patients with gestational diabetes mellitus(GDM).[Method]Totally128 pregnant women with GDM who had regular obstetrics and gynaecology outpatient checkups in the Department of Obstetrics and Gynaecology of Our Hospital were selected as the study subjects,and 128 pregnant women were randomly divided into 64 cases each in the observation group and the control group by using the random number table method.The control group received routine clinical treatment and health education,while the observation group was given vitamin D(400 IU/dose,1 time/day)combined with dietary management intervention,and the two groups were observed and compared in terms of glycemic control as well as maternal and fetal pregnancy outcomes.[Result]There was no difference between pregnant women in the observation group and the control group in terms of age,gestational week,BMI,education level,folic acid supplementation,regular exercise and daily outdoor activity time(P>0.05).There was no difference in the levels of FBG,HbA1c,2 h PG,HOMA-IR and FINS between the two groups before intervention,and the comparison between the groups was not statistically significant(P>0.05).After the intervention,the above indicators decreased in both groups,and the degree of decrease in pregnant women in the observation group with vitamin D and dietary management intervention was significantly higher than that in the control group(P<0.05),and the incidence of adverse pregnancy outcomes in mothers(4.69%vs.32.81%)and foetuses(3.13%vs.31.25%)was also significantly lower than that in the control group(P<0.001).[Conclusion]Vitamin D combined with dietary management adjuvant therapy can control blood glucose levels in GDM patients,reduce insulin resistance,and decrease the incidence of maternal and fetal adverse pregnancy outcomes.
万方数据
维普
