Association Between Folic Acid Level and Benign Prostatic Hyperplasia in American Men Over 65 Years Old
[Objective]Benign prostatic hyperplasia(BPH)is a common disease in middle-aged and elderly men,and folate level may be related to age.Therefore,this study aimed to analyze the relationship between folate and BPH.[Method]The data of NHANES population in the United States from 2001 to 2008 were selected.According to previous studies,folic acid was divided into five groups(Q1～Q5),and multivariate logistic regression analysis and subgroup analysis were performed by statistical software R and Free statistics.[Result]The study included 886 participants,of whom 690(77.9%)had BPH with a mean age of(68.1±10.6)years.Analysis showed that,after adjusting for potential confounding factors,higher serum and RBC folate levels were associated with an increased risk of BPH compared with the lowest quintile(Q1)(OR=2.07,95%CI:1.14—3.75,P=0.016;OR=1.73,95%CI:1.01—2.96,P=0.047),and dietary folic acid was not(OR=1.36,95%CI:0.78—2.38,P=0.279).Subgroup analysis showed that high levels of serum and RBC folate were associated with an increased risk of BPH in subgroups aged>65 years(OR=2.38,95%CI:1.2-4.74,P=0.014;OR=2.31,95%CI:1.22-4.39,P=0.01).[Conclusion]In individual elderly men in the United States,high levels of serum and erythrocyte folic acid may be risk factors for BPH.
dietary folic acidserum folateerythrocyte folatebenign prostatic hyperplasia(BPH)NHANES data base
万方数据
维普
