[Objective]Benign prostatic hyperplasia(BPH)is a common disease in middle-aged and elderly men,and folate level may be related to age.Therefore,this study aimed to analyze the relationship between folate and BPH.[Method]The data of NHANES population in the United States from 2001 to 2008 were selected.According to previous studies,folic acid was divided into five groups(Q1～Q5),and multivariate logistic regression analysis and subgroup analysis were performed by statistical software R and Free statistics.[Result]The study included 886 participants,of whom 690(77.9%)had BPH with a mean age of(68.1±10.6)years.Analysis showed that,after adjusting for potential confounding factors,higher serum and RBC folate levels were associated with an increased risk of BPH compared with the lowest quintile(Q1)(OR=2.07,95%CI:1.14—3.75,P=0.016;OR=1.73,95%CI:1.01—2.96,P=0.047),and dietary folic acid was not(OR=1.36,95%CI:0.78—2.38,P=0.279).Subgroup analysis showed that high levels of serum and RBC folate were associated with an increased risk of BPH in subgroups aged>65 years(OR=2.38,95%CI:1.2-4.74,P=0.014;OR=2.31,95%CI:1.22-4.39,P=0.01).[Conclusion]In individual elderly men in the United States,high levels of serum and erythrocyte folic acid may be risk factors for BPH.
关键词
膳食叶酸/血清叶酸/红细胞叶酸/良性前列腺增生/NHANES数据库
Key words
dietary folic acid/serum folate/erythrocyte folate/benign prostatic hyperplasia(BPH)/NHANES data base
维普
万方数据