Interaction Between Vitamin D and Obesity Based on Network Pharmacology
[Objective]To explore the interaction between vitamin D and obesity based on network pharmacology,and to explore the core proteins that affect the common targets of vitamin D and obesity.[Method]The targets of Vitamin D were obtained through the DrugBank database.The targets of Obesity were obtained through DisGeNET database.The intersection of Vitamin D targets and the targets of Obesity was obtained by the Venny platform.The common targets were imported into the String database to construct the protein-protein interaction(PPI)network,and the core proteins of protein-protein interaction were screened.[Result]Two targets of Vitamin D were obtained,and 2 821 targets of obesity disease were obtained.A common target of Vitamin D and obesity was obtained by the Venny platform,which was VDR.PPI network analysis showed that 8 proteins were the main proteins affecting the action of VDR,which were GC,CYP27B1,MED1,EP300,RXRA,NCOA3,SMAD3,CTNNB1.[Conclusion]Vitamin D may play an anti-obesity role by acting on the VDR target.GC,CYP27B1,MED1,EP300,RXRA,NCOA3,SMAD3 and CTNNB1 could interact with VDR,and affect the core protein of the common target of vitamin D and obesity.
万方数据
维普
