Causal Relationship Between Cereal Intake and The Risk of Osteoarthritis:A Two-Sample Mendelian Randomization Study
[Objective]To investigate the causal relationship between cereal intake and various phenotypes of osteoarthritis using Mendelian randomization.[Method]Mendelian randomization was employed to analyze the causal relationship between cereal intake and various phenotypes of osteoarthritis.Data were sourced from the Genome-Wide Association Study(GW AS)database,including GW AS data on cereal intake,osteoarthritis,knee osteoarthritis,and hip osteoarthritis.The primary Mendelian randomization analysis method used was the Inverse Variance Weighting(IVW)method.F-value statistics were calculated to test the stability of instrumental variables,and heterogeneity tests were conducted using Cochran's Q statistics and I2.Additionally,sensitivity and pleiotropy were assessed using the Weighted Median,MR-Egger regression,and leave-one-out methods.[Result]The results indicated a causal relationship between cereal intake and a reduced risk of osteoarthritis and knee osteoarthritis:osteoarthritis(OR=0.973,95％CI:0.949-0.998,P=0.035),knee osteoarthritis(OR=0.564,95％CI:0.357-0.889,P=0.014).However,there was no causal relationship between cereal intake and the risk of hip osteoarthritis(OR=0.602,95％CI:0.349-1.039,P=0.068).[Conclusion]The results suggested a causal relation-ship between cereal intake and a reduced risk of osteoarthritis and knee osteoarthritis,while no such causal relationship was observed with the risk of hip osteoarthritis.
万方数据
维普
