Relationship Between Serum Vitamin D Levels and Disease Progression in Patients with Type 2 Diabetic Nephropathy
[Objective]To explore the relationship between serum vitamin D levels and the progression of type 2 diabetic nephropathy.[Method]Totally120 patients with type 2 diabetic nephropathy treated in the Second People's Hospital of Hefei City from January 2021 to January 2024 were selected as the study objects.According to the 25-(OH)D3 value,120 subjects were divided into 3 groups:normal group 30 ng/mL≤25-(OH)D3≤100 ng/mL,insufficient group 20 ng/mL≤25-(OH)D3<30 ng/mL and deficiency group 25-(OH)D3<20 ng/mL.The quantitative values of glycosylated hemoglobin(HbA1c),serum creatinine,and 24h urinary albumin excretion(UAE)rate,and glomerular filtration rate(GFR)levels were compared between the three groups.We analyzed the association of 25-(OH)D3 with renal function markers in type 2 diabetes.[Result]There was no significant difference in gender,age,diabetes course and fasting blood glucose among 3 groups(P>0.05).The lower the level of 25-(OH)D3,the higher the level of HbA1c,serum creatinine and 24h-UAE,the lower the level of GFR(P<0.05).Pearson correlation analysis showed that 25-(OH)D3 level was not correlated with HbA1c(P>0.05),but was negatively correlated with serum creatinine,24h-UAE and GFR(P<0.05).[Conclusion]25-(OH)D3 has a certain relationship with the occurrence and development of type 2 diabetic nephropathy,and good vitamin D nutrition will play a role in preventing or slowing down the progression of disease.
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