Effect of Wheat Bran on Body Weight and Blood Lipid Levels in High-Fat Fed Rats
[Objective]To investigate the effect of wheat bran on body weight and blood lipid level in high-fat fed rats.[Method]A total of 24 SPF male SD rats were randomly divided into 4 groups,6 rats in each group,the normal control group was fed with normal diet,and the rest were fed with high-fat diet,among which the high-fat diet group was fed with high-fat feed containing 5%wheat dietary fiber,and the low-fat and high-dose wheat bran groups were fed with high-fat diet containing 10%and 15%wheat dietary fiber,respectively.Rats body weight and food intake are measured and recorded weekly.After 13 weeks of continuous feeding,they were sacrificed,and organ tis-sues and adipose tissues were weighed.Total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)are measured.Body weight,body length,Lee's index,fat index,serum indexes and liver histopathological morphology were compared in each group.[Result]Compared with the normal control group,the weight,body length and Lee's index of the high-fat diet group increased,and the liver,kidney,peritesticular fat,perirenal fat weight,peritesticular fat index,perirenal fat index,TC and LDL-C levels increased,and HDL-C levels decreased(P<0.05).Compared with the high-fat diet group,the Lee's index,liver,kidney,peritesticular fat weight,peritesticular fat index and perirenal fat index were decreased in the low-dose and high-dose wheat bran groups,the serum TC level and HDL-C level were decreased in the low-dose wheat bran group,the serum TG level and HDL-C level were increased in the high-dose group(P<0.05),and the degree of liver steatosis in the low-dose and high-dose wheat bran groups was significantly improved.[Conclusion]Wheat bran can improve the increase of body weight,blood lipid level and liver steatosis caused by high-fat diet,and play an important role in preventing the occurrence of dyslipidemia and obesity.
万方数据
维普
