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咖啡因对情绪作用的定性循证研究

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目的:旨在系统评价咖啡因摄入对情绪的影响。方法:以"咖啡因""情绪""心理""心情""抑郁""焦虑""压力""放松""快乐""多巴胺"为关键词,检索、整理并归纳2000年1月—2023年2月发表于PubMed、Embase、Medline、Cochrane、中国知网、万方和中国医学文献数据库,共7组数据库的中文及英文文献。根据中国食物与健康证据质量评价体系,对咖啡因的情绪改善效应进行综合评价。结果:共纳入文献23篇,其中1项Meta分析、18项随机对照试验、4项现况调查。单次摄入200 mg咖啡因有助于改善精神或体力疲劳相关的不良情绪,证据等级为良,推荐等级为B。咖啡因摄入70~400 mg/d与长期抑郁症发生风险呈负相关关系,证据等级为良,推荐等级为B。但是,摄入400 mg以上咖啡因或可增加焦虑程度,且男性、年轻女性及对咖啡因耐受度较低人群可能对咖啡因相关焦虑、压抑情绪更为敏感。结论:摄入咖啡因可对个体情绪产生影响,且咖啡因对情绪的作用可能受到剂量、性别、年龄、应用场景等因素的影响。
A Qualitative Evidence-Based Evaluation on The Impacts of Caffeine on Emotion and Mood
[Objective]To systematically evaluate the impacts of caffeine intake on mood.[Method]We searched and collected relevant Chinese and English literature published between January 2011 and July 2023 from seven databases,including PubMed,Embase,Medline,Cochrane,China National Knowledge Infrastructure,Wanfang,and Chinese Biomedical Literature Service System,us-ing search terms includes "caffeine","emotion","emotional","mood","mental","depression","anxiety","stress","relaxation","tenseness","alertness","jittery","happiness",and "dopamine".[Result]A total of 23 literatures includes 1 meta-analysis,18 random-ized controlled trials,and 4 cross-sectional studies,were included in the study. The single-dose caffeine intake ≥200 mg could improve one's negative emotions associated with mental and physical fatigue. The level of evidence is good,and the strength of recommendation is B. 70—400 mg daily caffeine intake is inversely associated with the prevalence of depressive symptoms. The level of evidence is good,and the strength of recommendation is B. However,caffeine intake ≥400 mg could lead to increased anxiety or tension. Males,young females,and those less tolerant to caffeine may be more sensitive to caffeine-related adverse emotional effects.[Conclusion]Consuming caffeine could impact one's mood,and the effect could be affected by multiple factors,such as dosage,gender,age,purpose,etc.

caffeineemotionmoodanxietydepression

林咏惟、周淑益、申贵元、曲畅、宋咏烨、方宇杰、张曼

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北京大学公共卫生学院营养与食品卫生学系,北京 100191

北京大学护理学院,北京 100191

咖啡因 情绪 情感 焦虑 抑郁

2024

中国食物与营养
中国农业科学院 国家食物与营养咨询委员会

中国食物与营养

CSTPCD
影响因子:0.754
ISSN:1006-9577
年,卷(期):2024.30(11)