Study on The Correlation Between Serum Vitamin D Levels and Combined Sarcopenia in Elderly Patients with Type 2 Diabetes Mellitus
[Objective]To determine the prevalence of comorbid sarcopenia in elderly patients with type 2 diabetes mellitus (T2DM) and to analyse the association between serum vitamin D levels and comorbid sarcopenia in elderly patients with T2DM.[Method]Totally 113patients with diabetes mellitus who visited our hospital from June 2022 to January 2024 were enrolled for the study. General information such as sex,age,years of education,history of smoking,history of alcohol consumption,height,weight,physical activity,laboratory data of serum 25(OH)D3 level test,step speed,grip strength and data of body composition test were collected from the elderly. Statistics on the prevalence of sarcopenia were performed with reference to the Asian sarcopenia working group,Diagnosis and Treatment of Skeletal Muscle Decrease Disorders 2019. The correlation between serum vitamin D level and comorbid sarcopenia in elderly patients with T2DM were analysed.[Result]The prevalence of elderly T2DM combined with sarcopenia was 25.66％,the mean serum 25(OH)D3 level was (25.14±6.33 )ng/mL,and the combined rate of vitamin D deficiency was 26.48％,which was significantly lower than that of patients in the T2DM alone group. Correlation analysis showed that serum 25(OH)D3 levels were positively correlated with step speed (r=0.508,P<0.05),grip strength (r=0.483,P<0.05),and ASMI scores in elderly patients with T2DM combined with sarcopenia (r=0.512,P<0.05). Analysis of factors affecting combined sarcopenia in elderly T2DM patients showed that older age,female sex,high fasting glucose,high HbA1c and low serum 25(OH)D3 levels were risk factors for cognitive impairment in elderly diabetic patients,and normal body weight was a protective factor,all P<0.05.[Conclusion]Elderly T2DM patients have a high incidence of combined sarcopenia,and low serum vitamin D level is an independent risk factor for combined sarcopenia and a good predictor. Therefore,serum vitamin D levels should be monitored in elderly T2DM patients to prevent the development of sarcopenia.
万方数据
维普
