Herpes simplex virus(HSV)is a ubiquitous enveloped virus containing double-stranded DNA.HSV-1 infection can cause inflammation of the lips,conjunctivitis and encephalitis,HSV-2 infection can cause genital herpes at many ages,and both viruses can establish lifelong latent infection in the body.Membrane fusion triggered by the interaction of various HSV membrane proteins is an important way for viruses to enter host cells.This review introduced the conserved core fusion mechanism of HSV composed of four viral glycoproteins gD,gH,gL and gB by analyzing the structure of glycoproteins and their interaction modes.Since there is currently no HSV vaccine approved for marketing in the world,it is of great significance to study the mode of action of HSV and host cells for the development of vaccines.
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