首页|基于结合纳米技术的细菌用于肿瘤诊疗的研究进展

基于结合纳米技术的细菌用于肿瘤诊疗的研究进展

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肿瘤诊疗始终是临床及基础科学的研究热点.近年,基于结合纳米技术的细菌已开发出多种肿瘤诊疗方法,与单纯的细菌诊疗方法比较,结合纳米技术的细菌诊疗方法可产生多重协同作用,从而提高肿瘤诊疗功效.将细菌的环境敏感性、趋向性、运动性和低氧生长等特性与纳米技术的可增加难溶药物溶解度、促进药物溶酶体逃逸、避免网状内皮系统吞噬清除等特性有机结合,构建新型细菌微/纳米诊疗平台,可实现肿瘤的精准诊断及药物控释.本文就近年结合纳米技术的细菌用于肿瘤诊疗的研究进展及其面临的挑战和可能的解决方案作一综述,以期为推动肿瘤诊疗研究的快速发展提供参考.
Advances in research on application of bacteria combined with nanotechnology for tumor diagnosis and treatment
Cancer diagnosis and treatment has always been a hot spot in clinical and basic scientific research.In recent years,scientists have developed a large number of tumor diagnosis and treatment methods based on bacteria combined with nanotechnology.Compared with pure bacterial diagnosis and treatment,bacterial diagnosis and treatment combined with nanotechnology can produce multiple synergistic effects,thereby improving the efficacy of tumor diagnosis and treatment.The characteristics of bacteria such as environmental sensitivity,tropism,motility and hypoxia growth combined organically with nanotechnology can increase the solubility of insoluble drugs,promote drug lysosomal escape,and avoid phagocytosis and clearance of the reticuloendothelial system to construct a new type of bacterial micro/nano diagnosis and treatment plat-form,thereby achieving the precise tumor diagnosis and controlled drug release.This paper reviewed the research progress of bacteria combined with nanotechnology for tumor diagnosis and treatment in recent years and the challenges and possible solutions,so as to provide reference for promoting the rapid development of tumor diagnosis and treatment research.

BacteriaNanotechnologyTumor diagnosis and treatment

薛鑫、张英英、王汉杰

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天津大学生命科学学院,天津 300072

徐州医科大学医学影像学院,江苏徐州 221004

细菌 纳米技术 肿瘤诊疗

国家重点研发计划国家自然科学基金优秀青年基金国家自然科学基金

2019YFA09065003212204731971300

2024

中国生物制品学杂志
中华预防医学会,长春生物制品研究所有限责任公司

中国生物制品学杂志

CSTPCD
影响因子:0.417
ISSN:1004-5503
年,卷(期):2024.37(1)
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