Ⅰ型人免疫缺陷病毒调控蛋白顺式转录激活因子的功能及其与疾病的相关性
Functions of HIV-1 Tat and its association with diseases
李远航 1陈睿鑫 1杜娟1
作者信息
- 1. 吉林大学白求恩第一医院转化医学研究院艾滋病与病毒研究所,吉林长春 130021
- 折叠
摘要
获得性免疫缺陷综合征(acquired immune deficiency syndrome,AIDS),又称艾滋病,一直是全球范围内公共卫生关注的重大传染病之一.Ⅰ型人免疫缺陷病毒(human immunodeficiency virus type 1,HIV-1)是导致AIDS的病原体,即使目前广泛采用的高效抗逆转录病毒疗法(鸡尾酒疗法)可有效抑制HIV-1的感染和复制,感染者依然会罹患其他疾病,如HIV-1相关的神经认知紊乱症(HIV-associated neurocognitive disorder,HAND).本文主要探讨HIV-1中重要的调控蛋白顺式转录激活因子(trans-activator of transcription,Tat)的功能,以及其与HIV-1复制及HAND的相关性,以明确研发靶向Tat蛋白的抗AIDS药物的重要性.
Abstract
Acquired immune deficiency syndrome,or AIDS,has been a major infectious disease that troubles the public health in a global scale.Human immunodeficiency virus type 1(HIV-1)is the causative reagent responsible for AIDS deve-lopment.Even though the highly active anti-retroviral therapy(HAART,or the cocktail therapy)that has been widely applied could effectively suppress the infection and replication of HIV-1,the infected people suffer from other related diseases,such as the HIV-associated neurocognitive disorder(HAND).This paper mainly focused on the function of an important regulatory protein of HIV-1,trans-activator of transcription(Tat),and its correlation with HIV-1 replication and HAND development,so as to clarify the importance of developing anti-AIDS drugs targeting Tat protein.
关键词
顺式转录激活因子/Ⅰ型人免疫缺陷病毒/神经认知紊乱症/获得性免疫缺陷综合征Key words
Trans-activator of transcription(Tat)/Human immunodeficiency virus type 1(HIV-1)/HIV-associated neuro-cognitive disorder(HAND)/Acquired immune deficiency syndrome(AIDS)引用本文复制引用
基金项目
国家自然科学基金面上项目(32170140)
吉林省自然科学基金(20210101314JC)
出版年
2024
NETL
NSTL
万方数据