抗片形吸虫病疫苗的研究进展
Research progress on vaccines against fascioliasis
李慈怀 1陈凤 2孙强明3
作者信息
- 1. 大理大学公共卫生学院,云南大理 671000
- 2. 云南省大理白族自治州血吸虫病防治研究所,云南大理 671000
- 3. 中国医学科学院北京协和医学院医学生物学研究所云南省重大传染病疫苗研发重点实验室,云南昆明 650118
- 折叠
摘要
片形吸虫病是由片形吸虫感染引起的人畜共患病,该病会引发机体的急慢性损伤,严重危害畜牧业发展,造成极大经济损失,目前用于治疗片形吸虫病的药物单一,且有耐药性产生,因此,急需更经济、可行的方式对家畜片形吸虫进行防治,以减少或避免人畜患病.疫苗是一种经济、有效的预防病原体感染的手段,有可能在片形吸虫病的预防中起到重要作用.本文就片形吸虫的抗原免疫应答机制及其疫苗研发现状作一综述,以期为片形吸虫病的防治提供科学参考和理论依据.
Abstract
Fascioliasis is a zoonotic disease caused by fasciola infection,which will cause acute and chronic damage to the body,seriously endanger the development of animal husbandry,and cause great economic losses.At present,the drugs used to treat fascioliasis are single with drug resistance occurring.Therefore,there is an urgent need for a more economical and feasible way to control Fasciola in livestock to reduce or avoid diseases in humans and animals.Vaccine is an economical and effective means to prevent pathogen infection,which may play an important role in the prevention of fascioliasis.In this paper,the antigenic immune response mechanism of fasciola and its vaccine research are reviewed,so as to provide scientific reference and theoretical basis for the control of fascioliasis.
关键词
片形吸虫病/危害/疫苗Key words
Fascioliasis/Hazards/Vaccine引用本文复制引用
基金项目
云南省高层次卫生健康技术人才培养专项(H-2018072)
国家寄生虫资源库项目(NPRC-2019-194-30)
出版年
2024
NETL
NSTL
万方数据