Research progress of antimicrobial peptides as potential biofilm inhibitors
Bacterial resistance to conventional therapies has become a major threat to human health,and the formation of biofilms has significantly increased the resistance of bacteria to antibiotics and the innate defense of the host to become the main virulence factor of microorganisms.Antimicrobial peptides(AMPs)have broad-spectrum antimicrobial properties and anti-biofilm activity,which have become potential therapeutic drugs.This review described biofilm formation,drug resistance and associated infections,with particular attention to the anti-biofilm potential of AMPs,highlighting their advantages,mechanism of action against planktonic bacteria,mechanism of anti-biofilm,and anti-biofilm activity in synergistic with antibiotics,so as to provide references for the application of AMPs in clinical biofilm-related drug-resistant bacterial infections.
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