巨噬细胞抗单纯疱疹病毒1型感染作用机制的研究进展
Progress in research on action mechanism of macrophages against herpes simplex virus type 1 infection
张振潇 1李琦涵1
作者信息
- 1. 中国医学科学院北京协和医学院医学生物学研究所云南省重大传染病疫苗研发重点实验室,云南昆明 650118
- 折叠
摘要
单纯庖疹病毒1型(herpes simplex virus type 1,HSV-1)是一种具有免疫逃逸、潜伏以及再感染能力的DNA病毒.尽管其生物学特性已被广泛研究,但目前尚未开发出专门针对HSV-1的治疗药物和预防性疫苗.HSV-1的感染能够引发宿主固有免疫和适应性免疫响应.其中,巨噬细胞通过病原体的吞噬、加工和提呈等过程,在抗病毒免疫反应中发挥着重要作用.本文对巨噬细胞在对抗HSV-1感染中作用的最新研究进展作一综述,以期为未来的疫苗设计和药物研发提供参考.
Abstract
Herpes simplex virus type 1(HSV-1)is a DNA virus renowned for its ability to evade the immune response,establish latency,and reinfect.Despite extensive research into its biological characteristics,there are no specific therapeu-tics or preventative vaccines currently available for HSV-1.Infection with HSV-1 triggers innate and adaptive immune respon-ses in the host,with macrophages playing a crucial role in antiviral immune responses through processes such as pathogen engulfment,processing,and presentation.This review aims to elucidate the latest research developments on the role of macro-phages in combating HSV-1 infection,in hopes of providing insights for future vaccine design and drug development.
关键词
单纯疱疹病毒/巨噬细胞/药物/疫苗Key words
Herpes simplex virus(HSV)/Macrophages/Drugs/Vaccine引用本文复制引用
基金项目
国家自然科学基金(82171817)
云南省自然科学基金(2020-01AUO70142)
出版年
2024
NETL
NSTL
万方数据