外泌体蛋白在肺癌发生发展中作用机制及诊断方面的研究进展
Research progress of exosomal proteins in occurrence,development mechanism and diagnosis of lung cancer
林真亭 1林榕 2陈梓悦 2兰天舒3
作者信息
- 1. 厦门医学院基础医学部,福建厦门 361023;机能与临床转化福建省高校重点实验室,福建厦门 361023
- 2. 厦门医学院基础医学部,福建厦门 361023
- 3. 厦门医学院基础医学部,福建厦门 361023;机能与临床转化福建省高校重点实验室,福建厦门 361023;厦门医学院呼吸病研究所,福建厦门 361023
- 折叠
摘要
目前,肺癌的早期筛查和监测是肺癌预防和治疗的关键.病理活检是原发性肺癌诊断的"金标准",但作为一种有创性诊断,不适于肺癌的早期筛查和随诊.研究发现,肿瘤来源的外泌体上富集了大量肿瘤相关性和特异性蛋白,通过血液和体液循环进行信息传递,在肿瘤的发生发展中发挥重要作用.因此,外泌体上的这些蛋白有望作为新的指标,通过无创性液体活检,进行肺癌的早期筛查和随诊.本文就外泌体蛋白在肺癌发生发展中的作用机制以及在肺癌诊断中的研究进展及存在的问题作一综述.
Abstract
At present,early screening and diagnosis of lung cancer are the key to the prevention and treatment of lung cancer.Pathological biopsy is the"gold standard"for the diagnosis of primary lung cancer.However,as an invasive diag-nosis,it is not suitable for early screening and follow-up of lung cancer.Studies have shown that tumor-derived exosomes are enriched in tumor-related and specific proteins,which transmit information through various body fluids and play an important role in the occurrence and development of tumors.Therefore,these proteins on exosomes are expected to serve as new indicators for early screening and follow-up of lung cancer through noninvasive liquid biopsy.This paper reviewed the mechanism of exosomal proteins in the occurrence and development of lung cancer and the research progress and existing problems in the diagnosis of lung cancer.
关键词
外泌体蛋白/肺癌/诊断/临床转化Key words
Exosomal protein/Lung cancer/Diagnosis/Clinical transformation引用本文复制引用
基金项目
福建省中青年教师教育科研项目(JAT200713)
厦门医学院大学生创新创业训练计划资助项目(202012631004)
厦门医学院大学生创新创业训练计划资助项目(2020-12631016)
厦门医学院大学生创新创业训练计划资助项目(202312631060)
厦门医学院呼吸疾病研究所课题(HXJB-17)
出版年
2024
NETL
NSTL
万方数据