猪繁殖与呼吸综合征病毒及其疫苗的研究进展
Research progress in porcine reproductive and respiratory syndrome virus and vaccine against it
杜炎斌 1赵小刚 2朱利塞1
作者信息
- 1. 广东海大畜牧兽医研究院 广东省养猪与猪病防控技术研究企业重点实验室,广东广州 511400
- 2. 广东海大集团股份有限公司,广东广州 511400
- 折叠
摘要
猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)亦称蓝耳病,是由猪繁殖与呼吸综合征病毒(porcine reproductive and respiratory syndrome virus,PRRSV)引起的免疫抑制性疾病.PRRSV是一种重要的猪传染性病原,具有易重组变异、传播能力强的特点,于全球范围内广泛传播.同时,由于该病原具有免疫抑制、免疫逃避、易导致抗体依赖增强作用(antibody-dependent enhancement,ADE)的特性,给PRRS的防控及相关疫苗的研发带来了严峻挑战.本文就PRRSV致病过程、免疫逃避机制及不同类型PRRSV疫苗的研究进展作一综述,以期为后续相关疫苗的研发提供思路.
Abstract
Porcine reproductive and respiratory syndrome(PRRS),also known as blue ear disease,is an immunosuppres-sive disease caused by porcine reproductive and respiratory syndrome virus(PRRSV).PRRSV is an important infectious pathogen of porcine,which has the characteristics of easy recombination and mutation,high transmission ability,and has been widely spread in the world.At the same time,because of the characteristics of immunosuppression,immune evasion,and easy-to-cause antibody-dependent enhancement(ADE),the pathogen has brought serious challenges to the disease pre-vention and control of PRRS and the development of related vaccines.In this paper,the pathogenic process of PRRSV,immune evasion mechanism,and research progress in different types of PRRSV vaccines were reviewed,in order to provide ideas for the development of related vaccines in the future.
关键词
繁殖与呼吸综合征病毒/免疫机制/减毒活疫苗/灭活疫苗Key words
Porcine reproductive and respiratory syndrome virus(PRRSV)/Immune mechanism/Live attenuated vaccine/Inactivated vaccine引用本文复制引用
基金项目
广东省科技计划项目(2020B-212070023)
出版年
2024
NETL
NSTL
万方数据