猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)亦称蓝耳病,是由猪繁殖与呼吸综合征病毒(porcine reproductive and respiratory syndrome virus,PRRSV)引起的免疫抑制性疾病.PRRSV是一种重要的猪传染性病原,具有易重组变异、传播能力强的特点,于全球范围内广泛传播.同时,由于该病原具有免疫抑制、免疫逃避、易导致抗体依赖增强作用(antibody-dependent enhancement,ADE)的特性,给PRRS的防控及相关疫苗的研发带来了严峻挑战.本文就PRRSV致病过程、免疫逃避机制及不同类型PRRSV疫苗的研究进展作一综述,以期为后续相关疫苗的研发提供思路.
Research progress in porcine reproductive and respiratory syndrome virus and vaccine against it
Porcine reproductive and respiratory syndrome(PRRS),also known as blue ear disease,is an immunosuppres-sive disease caused by porcine reproductive and respiratory syndrome virus(PRRSV).PRRSV is an important infectious pathogen of porcine,which has the characteristics of easy recombination and mutation,high transmission ability,and has been widely spread in the world.At the same time,because of the characteristics of immunosuppression,immune evasion,and easy-to-cause antibody-dependent enhancement(ADE),the pathogen has brought serious challenges to the disease pre-vention and control of PRRS and the development of related vaccines.In this paper,the pathogenic process of PRRSV,immune evasion mechanism,and research progress in different types of PRRSV vaccines were reviewed,in order to provide ideas for the development of related vaccines in the future.
Porcine reproductive and respiratory syndrome virus(PRRSV)Immune mechanismLive attenuated vaccineInactivated vaccine
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