Research progress on application of SARS-CoV-2 pseudovirus in biotechnological drug effectiveness evaluation
At present,SARS-CoV-2 is still constantly evolving and mutating,with weakened pathogenicity but faster transmis-sion,which still threatens human health.Anti-SARS-CoV-2 biotechnological drugs are still the hotspot of research and develop-ment in the field of biomedicine,and the effectiveness evaluation is very important for screening these drugs.Traditional effectiveness evaluation of anti-SARS-CoV-2 biotechnological drugs requires the live virus of SARS-CoV-2 that is difficult to obtain,and the requirement of high experimental conditions has limited the research and development of anti-SARS-CoV-2 biotechnological drugs.SARS-CoV-2 pseudovirus can simulate the infectivity of live virus,but it has no infectivity of live virus,and is safe and easy to prepare,which is a favorable tool for evaluating the effectiveness of SARS-CoV-2 biotechnological drugs.In this paper,the epidemiological characteristics of SARS-CoV-2,the packaging system of SARS-CoV-2 pseudovirus and the application of SARS-CoV-2 pseudovirus in the effectiveness evaluation of biotechnological drugs were reviewed,so as to provide a reference for the application of SARS-CoV-2 pseudovirus in the development and quality evaluation of bio-technological drugs.
NETL
NSTL
万方数据
