Advances in regulation of exosome non-coding RNA on innate immune cells
Innate immune cells play an important role in anti-infection and anti-tumor immunity of the body.Common innate immune cells mainly include macrophages,natural killer(NK)cells,dendritic cells(DCs)and neutrophils.Exosomes,as a new subcellular entity,can regulate the biological activity of recipient cells by transporting non-coding RNA(ncRNA)such as mi-croRNA(miRNA),long non-coding RNA(lncRNA)and circular RNA(circRNA)when circulating in extracellular space.Among them,miRNA induces gene silencing by directly targeting mRNA,while lncRNA and circRNA can act as miRNA sponges to adsorb and inhibit miRNA,indirectly regulating protein expression.In this paper,the regulatory role of exosome ncRNA in innate immune cells has been reviewed,so as to provide a theoretical basis for the study of innate immunity regulation and immune-related diseases.
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