Research progress on function of phosphatase 1 nuclear targeting subunit(PNUTS)in tumorigenesis
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蛋白磷酸酶1(phosphatase 1,PP1)的调节亚基有200多个,其中磷酸酶1核靶向亚基(phosphatase 1 nuclear targeting subunit,PNUTS)参与PP1的去磷酸化过程,调控PP1的活性及亚细胞定位,也可通过与特定调节蛋白结合,调节细胞周期进程和中心体成熟和分裂.PNUTS可调控多个与肿瘤形成相关蛋白的功能,如与癌蛋白MYC结合可调控其转录功能,与抑癌因子同源磷酸酶张力蛋白(phosphatase and tensin homolog,PTEN)结合可抑制其对PI3K-AKT信号通路的负向调节.另外,PNUTS还与Caspase蛋白家族介导的细胞凋亡有关.本文就PNUTS结构及其在肿瘤形成中作用的研究进展作一综述,以期为寻找肿瘤治疗新靶点提供参考.
There are more than 200 regulatory subunits of protein phosphatase 1(PP1),among which phosphatase 1 nuclear targeting subunits(PNUTS)are involved in the dephosphorylation process of PP1,regulate the activity and subcellular localiza-tion of PP1,and can also regulate the cell cycle process and centrosome maturation and division by binding to specific regulatory proteins.PNUTS can regulate the functions of many proteins related to tumorigenesis,for example,bind to onco-gene MYC to regulate its transcription function,and bind to tumor suppressor phosphatase and tensin homolog(PTEN)to inhibit its negative regulation on PI3K-AKT signaling pathway.In addition,PNUTS are also related to the cell apoptosis mediated by Caspase protein family.In this paper,the structure of PNUTS and the role in tumorigenesis are reviewed in order to provide a reference for finding new targets for tumor treatment.
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