Reported incidence of adverse reactions in plateletpheresis donors in China:a meta-analysis
Objective To analyze the overall situation and main influencing factors of adverse reactions of blood dona-tion of apheresis platelet donors in China by systematic review,and to provide basis for preventing and controlling adverse reactions of platelet donation and improving the quality of blood donation service.Methods CNKI,VIP,Wanfang Data,Pubmed and Embase databases were searched to collect cross-section studies on adverse reactions of platelet donation in Chi-na.The observation period was ≥ 6 months,and the retrieval time was from 1998 to March 2023.The studies were inde-pendently screened by 2 evaluators according to the inclusion and exclusion criteria.Data extraction and literature quality e-valuation were carried out,and meta analysis was performed by Stata 14.0 software.Results A total of 91 literature invol-ving 585 769 apheresis platelet donors were included,and 9 102 of them had adverse reactions.Random effect model meta-analysis showed that the total incidence of adverse reactions of platelet donation was 2.65％[95％CI(2.04,3.45),P＜0.000 1].Subgroup analysis showed that the incidence of platelet donation adverse reactions in the eastern,central and western regions were 2.63％[95％CI(1.94,3.58)],2.32％[95％CI(1.29,4.16)]and 4.10％[95％CI(1.90,8.83)],respectively,with regional differences(P＜0.000 1).The incidence of adverse reactions of different degrees was 3.62％[95％CI(2.69,4.86)]for non-severe and 0.28％[95％CI(0.18,0.45)]for severe.The incidence of adverse reactions of blood donation was also different among different apheresis instruments(P＜0.000 1):Amicus 2.73％[95％CI(1.23,6.06)],CS3000 series 3.59％[95％CI(2.64,4.89)],MCS+series 3.42％[95％CI(2.23,5.25)],Trima 4.86％[95％CI(3.08,7.66)],other groups 1.71％[95％CI(0.15,20.02)].In addition,the incidence of adverse reactions was 4.80％[95％CI(3.05,7.55)]in females and 1.39％[95％CI(0.90,2.15)]in males,with the incidence in females high-er than that in males(P＜0.000 1).The adverse reactions of platelet donors under 30 years old and over 30 years old were 2.31％[95％CI(1.34,3.98)]and 1.95％[95％CI(1.19,3.20)],respectively,and there was no statistically significant difference(P＞0.01).The incidence of adverse reactions of blood donation for first-time donors and repeat donors was 2.16％[(95％CI(1.18,3.95)]and 1.12％[(95％CI(0.35,3.58)],with the former higher than the latter(P＜0.000 1).The incidence of adverse reactions for single and double platelet collection was 1.67％[95％CI(0.57,4.89)]and 3.13％[95％CI(1.11,8.86)]respectively,with no significant difference(P＞0.01).Conclusion It's suggested to unify the mo-nitoring standards of adverse reactions of apheresis platelet donation,understand and master the factors that affect the ad-verse reactions of apheresis platelet donors,so as to improve the quality of apheresis platelet donation service and ensure the safety of donations.
apheresis plateletsmeta-analysisadverse reactions of blood donation
万方数据
维普
