Plasma exchange(PE)is effective in a part of autoimmune diseases,and its main action mechanisms in-clude removing pathogenic factors from the patient's blood,regulating immune function,replenishing normal plasma compo-nents.The use of PE in the treatment of severe immune-related skin diseases,such as pemphigus vulgaris,toxic epidermal necrolysis and clinically amyopathic dermatomyositis,has become more widespread.This review provides an overview of the progress of PE application in severe immune-related skin diseases at home and abroad in recent years to provide new ideas for the treatment of clinical severe skin diseases.
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