IgA缺乏型过敏性输血反应(allergic transfusion reactions，ATRs)常发生于产生抗-IgA的IgA缺乏症患者，当这些患者输注含有IgA的血液产品时，可导致过敏性输血反应，严重者可致死。我们对IgA缺乏症(immunoglobu-lin A deficiency，IgAD)的临床表现及影响因素，以及IgA缺乏导致的过敏性输血反应发病机制、实验室检测和防治策略进行综述，从而提高医务工作者对IgA缺乏型过敏性输血反应的认识和防范意识。
IgA deficiency allergic transfusion reaction and its prevention and treatment strategies
IgA deficiency allergic transfusion reaction often occurs in patients with anti-IgA.When blood products con-taining IgA are transfused into these patients,it may lead to severe allergic transfusion reactions,which can be fatal in se-vere cases.This review summarizes the clinical manifestations and influencing factors of immunoglobulin A deficiency(IgAD),as well as the pathogenesis,laboratory test and prevention strategies of allergic transfusion reactions caused by IgA deficiency,so as to enhance prevention awareness of IgA deficiency allergic transfusion reaction in medical staff.
IgA deficiencyallergic transfusion reactionsanti-IgAprevention and treatment
国家科技期刊平台
NSTL
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